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Symbol
Name
ID 		Braf
Braf transforming gene
MGI:88190
Phenotype annotations related to endocrine/exocrine glands
Darker colors indicate more annotations
Human Phenotypes
Diabetes mellitus
Exocrine pancreatic insufficiency
Pancreatic adenocarcinoma
Goiter
Non-medullary thyroid carcinoma
Papillary thyroid carcinoma
Disease(s) Associated with BRAF
pancreatic cancer
thyroid gland papillary carcinoma

Mouse Phenotypes
increased thymocyte apoptosis
abnormal pancreatic acinar cell morphology
abnormal crypts of Lieberkuhn morphology
abnormal large intestine crypts of Lieberkuhn morphology
abnormal adenohypophysis morphology
small adenohypophysis
abnormal thymus morphology
decreased thymus weight
thymus atrophy
decreased thymocyte number
abnormal thyroid gland morphology
abnormal thyroid follicle morphology
enlarged thyroid gland
abnormal skin sebaceous gland morphology
ovary cyst
increased gland tumor incidence
increased pheochromocytoma incidence
increased thyroid tumor incidence
increased thyroid carcinoma incidence
decreased activity of thyroid gland
Availability Mouse Genotype
Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Braftm1Bbd/Braf+
Braftm1Cpri/Braftm1Cpri
Tg(TPO-cre)1Shk/0  (conditional)
Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0  (conditional)
Braftm1Mmcm/Braf+  (conditional)
Braftm1Mmcm/Braf+
Tg(Tg-cre/ERT2)#Mmcm/0  (conditional)
Braftm1Mmcm/Braf+
Tg(TPO-cre/ERT2)1139Tyj/0  (conditional)
Braftm1Sva/Braftm1.1Sva
Tg(Nes-cre)1Kln/0  (conditional)
Braftm1Tumg/Braf+
Tg(CAG-cre)2Osb/0  (conditional)
Braftm1Wds/Braftm1.1Wds
Tg(Nes-cre)1Kln/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory